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Transcriptional effects of bipolar disorder drugs on NT2-N cells

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NIAID Data Ecosystem2026-03-13 收录
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Human neuronal-like cells (NT2-N) were treated with either lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), valproate (0.5 mM) or vehicle control for 24 hours. Genome wide mRNA expression was quantified by RNA-sequencing. Results offer insights on the mechanism(s) of action of bipolar disorder drugs at the transcriptional level. Transcription profiles of NT2-N cells after 24-hour treatments with one of the four bipolar disorder drugs or their respective vehicle

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2022-04-27
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