Diseases of Base Excision Repair

Germline mutations, single nucleotide polymorphisms (SNPs) and somatic mutations in several genes involved in base excision repair (BER), a DNA repair pathway where a damaged DNA base is excised and replaced with a correct base, are involved in the development of cancer and several other oxidative stress-related diseases. For review, please refer to Fu et al. 2012, Fletcher and Houlston 2010, Brenerman et al. 2014, Patrono et al. 2014, and D'Errico et al. 2017.

基线突变、单核苷酸多态性（SNPs）以及多个参与碱基切除修复（BER）途径的基因中的体细胞突变，该途径涉及受损DNA碱基的切除并替换为正确的碱基，这些突变与癌症以及多种与氧化应激相关的疾病的发生发展密切相关。欲了解更多信息，请参阅Fu等（2012年）、Fletcher和Houlston（2010年）、Brenerman等（2014年）、Patrono等（2014年）以及D'Errico等（2017年）的综述。