Frequency comparison of between the observed and correlated mutation sets for HLA B*15 and HLA B*48.

Results of the Fisher's exact test between observed and expected counts of L90M in sequence sets from patients annotated with B*15+, B*48+, B*15+ or B*48+, and a pool of random patients. The expected L90M counts for each associated PI resistance mutation were calculated with the linear models described elsewhere in this article. The 66.7% confidence intervals were calculated from a bootstrapped sets obtained from resampling the sequence sets and applied to the linear models. The observed L90M frequencies were significantly lower than the expected L90M frequencies.