Predicted structures of 37 SLC-protein complexes and controls

Solute carrier (SLC) transporters form a major superfamily which transport a wide range of substrates across cellular and organellar membranes. To study their regulation on protein level and position SLCs in the human interactome, we conducted a large-scale interrogation of the protein-protein interactions (PPIs) of SLCs employing affinity purification combined with mass spectrometry (AP-MS). This study resulted in thousands of novel protein interactions of SLCs. For a small subset of SLC protein complexes, we performed structural predictions using AlphaFold2 multimer (v2.2 and v2.3). The dataset attached contains the structures in PDB format. The structures were further discussed in the associated manuscript. In addition, an annotation table is provided, which summarizes the scores for each modelled complex.