Chaperone dependent coordination of nutrient sensing and energy metabolism by mTORC2

mTORC2 senses nutrients and coordinates substrate metabolism and macromolecule synthesis program with the availability of external nutrient availability. Knockdown of mTORC2 components and its chaperone partners impairs both nutrient sensing and downstrem metabolism/growth programs. adenovirus-mediated knockdown of Dnajb9 and Rictor with their respective lacZ control groups in mouse liver.