Structure of CHK1 10-pt. mutant complex with LRRK2 inhibitor 24
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Structure of CHK1 10-pt. mutant complex with LRRK2 inhibitor 24 Descriptor: (3R,4R)-4-{4-[6-chloro-2-({1-[(1R)-2,2-difluorocyclopropyl]-5-methyl-1H-pyrazol-4-yl}amino)quinazolin-7-yl]piperidin-1-yl}-4-methyloxolan-3-ol, Serine/threonine-protein kinase Chk1 Authors: Palte, R.L. Deposit date: 2021-11-17 Release date: 2022-01-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.299 Å) Cite: Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J.Med.Chem., 65, 2022
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2021-11-17
