Ko [1×10−25molecules−1m3] and Гexc for various parameter conditions.

Ko values are calculated by 100 independent simulation runs of 3DSOLM for the 1% pure reactant case in 100 nm×100 nm×100 nm for varying B, M, D, and α cases and 400 nm×400 nm×Height (H nm) for different heights of simulation boxes. Except for the specific parameter examined in each experiment, all parameter values are set to the default values: B = 0.7, M = 1.0 ns, D = 4.6×10−11 m2s−1, α = 2.0, β = 1.0, dth = 0.125 nm in 3DSOLM.