USP7 Covalently Bound to N-(6-Fluoro-3-nitropyridin-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-amine (GCL36, 7a) with Partial Occupancy
收藏Protein Data Bank Japan2026-04-15 更新2026-04-19 收录
下载链接：
https://pdbj.org/mine/summary/9qje
下载链接
链接失效反馈官方服务：
资源简介：
USP7 Covalently Bound to N-(6-Fluoro-3-nitropyridin-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-amine (GCL36, 7a) with Partial Occupancy Descriptor: 1,2-ETHANEDIOL, 5-(1-methyl-1H-pyrazol-4-yl)-N-(3-nitropyridin-2-yl)isoquinolin-3-amine, BROMIDE ION, ... Authors: Stahlecker, J, Ernst, L.N, Gehringer, M, Stehle, T, Boeckler, F.M. Deposit date: 2025-03-19 Release date: 2025-09-10 Last modified: 2026-04-15 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Design, Synthesis, and Molecular Evaluation of S N Ar-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode. Arch Pharm, 358, 2025
创建时间：
2025-03-19
