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Effect of MLL3 deletion in mammary stem cells. Mus musculus

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA317474
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MLL3 inactivation mutations occurs frequently in human breast cancer. To understand the function of MLL3 inactivation, we compared the gene expression profiles of the vector control (WT) and Mll3-null mouse mammary stem cells generated by CRISPR. Affymetrix mouse Gene 2.0ST ships were used for microarray. Overall design: Mammary stem cell lines were generated by CRISPR. Total RNA was extracted from stem cells cultured as organoids and used for microarray analysis.
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2016-04-05
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