Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging II. Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging II

To gain insight into the mechanisms by which exercise affects circulating immune cells, we subjected young and old mice to aerobic exercise and performed single cell transcriptome analysis of circulating immune cells from these animals. Overall design: Circulating immune cells were isolated from the blood of exercised or control young (4-month old) and old (22-month old) mice and processed for single cell RNA-seq.