Metabolic vulnerabilities of aneuploid mammary epithelial cells
收藏NIAID Data Ecosystem2026-05-02 收录
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资源简介：
We performed genome-wide CRISPR knockout screens in isogenic aneuploid/diploid human mammary epithelial cells to identify synthetic lethalities associated with supernumerary chromosomes. We identify several aneuploidy-associated metabolic vulnerabilities from these CRISPR screens, and perform follow-up studies including RNA-seq analysis to identify stress signaling pathways associated with metabolic stress.
创建时间：
2024-09-26
