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Organocatalyzed Asymmetric Oxidative Coupling of α‑Csp3‑H of Tertiary Amines to α,β-Unsaturated γ‑Butyrolactam: Synthesis of MBH-Type Products

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Figshare2016-02-16 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Organocatalyzed_Asymmetric_Oxidative_Coupling_of_Csp_sup_3_sup_H_of_Tertiary_Amines_to_Unsaturated_Butyrolactam_Synthesis_of_MBH_Type_Products/2244244
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A unique organocatalytic asymmetric oxidative cross-dehydrogenative coupling of a α-Csp3-H bond of tertiary amines with α,β-unsaturated γ-butyrolactams to generate Morita–Baylis–Hillman-type products has been realized for the first time. This method provides an efficient way to access a series of α-heterocyclic optically active tetrahydroisoquinoline scaffolds.
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2016-02-16
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