VIM-2 in complex with GKV61 (5c) - dynamically chiral phosphonic acid-type metallo-beta-lactamase inhibitors

NIAID Data Ecosystem2026-05-02 收录

金属β-内酰胺酶抑制剂

抗菌药物设计

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VIM-2 in complex with GKV61 (5c) - dynamically chiral phosphonic acid-type metallo-beta-lactamase inhibitors

创建时间：

2025-05-07

Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor

蛋白质-配体复合物结构

抗菌药物设计

Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor Descriptor: N-{[3-(2H-indazol-5-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, cytoplasmic, ... Authors: Hi

Protein Data Bank Japan2024-10-16 更新30

Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7 complexed with compound CS319

金属β-内酰胺酶抑制剂

细菌耐药性机制

Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7 complexed with compound CS319 Descriptor: (3R,5R,7aS)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Beta-

Protein Data Bank Japan2024-02-28 更新10

Coupled Hydrogen-Bond–Electrostatic Recognition of Phosphatidylglycerol Drives the Design of Resistance-Suppressing Miniature Peptidomimetics

抗菌药物设计

靶向治疗耐药

The emergence of multidrug-resistant (MDR) pathogens has urged us to find new antimicrobial strategies. Phosphatidylglycerol (PG) is an attractive bacterial-specific lipid target but is targeted by on

NIAID Data Ecosystem00

Expanding the Landscape of Dual Action Antifolate Antibacterials through 2,4-Diamino-1,6-dihydro-1,3,5-triazines

抗菌药物设计

二氢叶酸还原酶抑制剂

Antibiotics that operate via multiple mechanisms of action are a promising strategy to combat growing resistance. Previous studies have shown that dual action antifolates formed from a pyrroloquinazol

NIAID Data Ecosystem20

Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(UCP11153TM) and NADPH

药物靶点结构解析

抗菌药物设计

Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(UCP11153TM) and NADPH Descriptor: 5-[(3R)-3-(5

Protein Data Bank Japan2024-02-21 更新10

VIM-2 in complex with GKV61 (5c) - dynamically chiral phosphonic acid-type metallo-beta-lactamase inhibitors

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