Covalent inhibitor VVD-442 bound to the RAS binding domain (RBD) of PI3Ka

Protein Data Bank Japan2025-11-26 更新2026-04-25 收录

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Covalent inhibitor VVD-442 bound to the RAS binding domain (RBD) of PI3Ka Descriptor: 1-[(1P)-5-bromo-2'-chloro[1,1'-biphenyl]-2-sulfonyl]-4-fluoro-N-[(2S)-4-(methanesulfonyl)butan-2-yl]piperidine-4-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Authors: Bernard, S.M, Tamiya, J. Deposit date: 2024-11-05 Release date: 2025-01-01 Last modified: 2025-11-26 Method: X-RAY DIFFRACTION (2.827 Å) Cite: Covalent inhibitors of the PI3K alpha RAS binding domain impair tumor growth driven by RAS and HER2. Science, 390, 2025

创建时间：

2024-11-05