Comparison of the shared amino acid 6-mer words with the greatest average sequence score among gram-positive free-living (Free) and pathogenic (Path) microbes.

NOTE: The gram-positive FREE and PATH dictionaries used in the LDA analysis for Fig. 4 were merged into an “averaged” dictionary of 6-mer amino acid words that were present in both groups. The common 6-mer words with the largest difference (expressed as a ratio) in selection scores between FREE and PATH word distance were aligned against NCBI’s Conserved Domain Database to identify potential proteins in which these words appear.(1) Conserved Domain Database: http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml.(2) Cross-referenced database entry within CDD.