Bulk skeletal muscle eQTL meta-analysis summary statistics (GTEx + FUSION)

Datasets linked to the submitted manuscript titled: "Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits" Summary statistics from the eQTL meta-analysis of bulk skeletal muscle in GTEx (v8) and FUSION. Supplemental tables S2 and S3 (lists of lead variants for all distinct signals in hg38 and hg19) Column Label Column Description Gene symbol Gene symbol Gene Ensembl ID for gene GENCODE v19 Chr Chromosome Pos Position EA Effect allele NEA Non-effect allele EAF Effect allele frequency Beta Variant to gene effect for the joint model with all signals for the effect allele SE Standard error Pvalue_joint P-value of the joint model with all the eQTL variants that pass the 1e-5 stepwise threshold Studies (1=FUSION, 2=GTEx) Studies contributing to meta-analysis of this gene Signal number for eGene (Current:Total) Variant's signal number out of all signals for the eGene (for instance, 2:03 means this was the second signal identified out of three for this eGene) BH-adjusted p-value FDR-adjusted p-value accounting for independent tests within this eGene Full marginal eQTL summary statistics (Muscle_eQTL_MetaAnalysis_fullMarginalSumStats_hg38.tar.gz and Muscle_eQTL_MetaAnalysis_fullMarginalSumStats_hg19.tar.gz) Column Label Column Description gene Ensembl ID for gene GENCODE v19 SNP_hg* Marker name of the SNP with the alleles formatted alphabetically (chr_pos_A1_A2) chr Chromosome pos Position EA Effect allele NEA Non-effect allele beta Marginal variant to gene effect for the effect allele se Standard error pval Marginal p-value studies Studies contributing to meta-analysis of this gene (1=FUSION, 2=GTEx) Conditionally isolated eQTL summary statistics for each signal (Muscle_eQTL_MetaAnalysis_fullAB1SumStats_hg38.tar.gz and Muscle_eQTL_MetaAnalysis_fullAB1SumStats_hg19.tar.gz) Column Label Column Description gene Ensembl ID for gene GENCODE v19 SNP_hg* Marker name of the SNP with the alleles formatted alphabetically (chr_pos_A1_A2) chr Chromosome pos Position EA Effect allele NEA Non-effect allele beta Variant to gene effect for the joint model with all signals for the effect allele; if the gene has only one signal, the marginal beta is provided se Standard error pval If the gene has more than one signal, the conditional joint p-value is provided; otherwise, the marginal p-value is provided lead_SNP_hg* If the gene has more than one signal, this is the lead variant of the signal for which conditional statistics are provided; if the gene has only one signal, this is "NA" studies Studies contributing to meta-analysis of this gene (1=FUSION, 2=GTEx) SNP_N SNP sample size gene_N Gene sample size