Traditional attempts to model genotoxicity data have been limited to congeneric data sets, primarily because the mechanism of action was ignored, and frequently, the chemicals required metabolism to t
SimRFlow is a high-throughput physiologically based pharmacokinetic (PBPK) modelling tool which uses Certara’s Simcyp® simulator. The workflow is comprised of three main modules: 1) a Data Collection
Trivial lethal—atleast one of the reactions in the double deletion pair is lethal in a single reaction deletion Non-trivial lethal, single—reaction involved in the single deletion is lethal Non-trivia
