Additional file 1 of Plasma metabolomics profiles in Black and White participants of the Adventist Health Study-2 cohort

Additional file 1: Supplementary Table 1. Dietary intakes of study participants. Supplementary Table 2. All metabolites present at higher abundance in Black relative to White participants at FDR < 0.05 in simplest model. Supplementary Table 3. All metabolites present at lower abundance in Black relative to White participants at FDR < 0.05 in simplest model. Supplementary Table 4. Metabolites (n = 348) present at lower abundance in Black relative to White participants at FDR < 0.05. Supplementary Table 5. Metabolites present at higher abundance in Black relative to White participants at FDR < 0.05 (with additional adjustment for BMI and dietary pattern). Supplementary Table 6. Metabolites present at lower abundance in Black relative to White participants at FDR < 0.05 (with additional adjustment for BMI and dietary pattern). Supplementary Table 7. Metabolites present at higher abundance in Black relative to White participants at FDR < 0.05 (with additional adjustment for BMI, dietary pattern, exercise, social vulnerability index, and psychosocial stress). Supplementary Table 8. Metabolites present at lower abundance in Black relative to White participants at FDR < 0.05 (with additional adjustment for BMI, dietary pattern, exercise, social vulnerability index, and psychosocial stress). Supplementary Table 9. Metabolites present at lower abundance in Black relative to White participants at FDR < 0.05 excluding pilot study participants. Supplementary Table 10. Metabolites present at lower abundance in Black relative to White participants at FDR < 0.05 in pilot study participants. Supplementary Table 11. Differentially abundant metabolites in common between analyses with pilot (n = 93) and non-pilot (n = 258) study participants at FDR<0.05. Supplementary Table 12. Metabolite subclasses associated with race (Black vs White) at FDR in simplest model < 0.05. Supplementary Table 13. Metabolite subclasses associated with race (Black vs White) at FDR < 0.05 (adjusted additionally for BMI and dietary pattern). Supplementary Table 14. Metabolite subclasses associated with race (Black vs White) at FDR < 0.05 (adjusted additionally for BMI, dietary pattern, social vulnerability index, and psychosocial stress). Supplementary Table 15. Names of statistically significant component metabolites (based on linear regression analysis) contained within each subclass differentially abundant at FDR < 0.05. Supplementary Table 16. Differentially abundant subclasses in common between analyses with pilot (n = 93) and non-pilot (n = 258) study participants at FDR<0.05. Supplementary Table 17. Results from pathway analysis of metabolic pathways over-represented comparing Black and White participants (at P ≤ 0.5). Supplementary Table 18. Metabolites differentially abundant in Black relative to White participants at FDR < 0.05 (adjusted additionally for dietary pattern, dietary fat (polyunsaturated, monounsaturated, and saturated), education, social vulnerability index, exercise, BMI, coffee, medication use, chronic disease cardiovascular disease, diabetes, hypertension). Supplementary Table 19. Metabolite subclasses associated with race (Black vs White) at FDR < 0.05 (adjusted additionally for BMI, dietary pattern, social vulnerability index, psychosocial stress, and dietary fat). Supplementary Table 20. Metabolites present at higher abundance in Black relative to White participants at FDR < 0.05 in n = 140 study participants with plasma creatinine measurements (and adjustment for eGFR). Supplementary Table 21. Metabolites present at higher abundance in Black relative to White participants at FDR < 0.05 in n = 140 study participants with plasma creatinine measurements. Supplementary Table 22. Metabolite subclasses associated with race (Black vs White) in subset of study participants with plasma creatinine (and adjustment for eGFR) at FDR < 0.05. Supplementary Table 23. Metabolite subclasses associated with race (Black vs White) in subset of study participants with plasma creatinine at FDR < 0.05.