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Atomic Structure of a Short α-Helix Stabilized by a Main Chain Hydrogen-Bond Surrogate

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https://figshare.com/articles/dataset/Atomic_Structure_of_a_Short_Helix_Stabilized_by_a_Main_Chain_Hydrogen_Bond_Surrogate/2947831
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Herein we report the 1.15 Å X-ray crystal structure of a short α-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon−carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived α-helix truly resembles the structure of canonical α-helices and provides unequivocal support for our helix nucleation strategy.
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2016-06-03
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