Atomic Structure of a Short α-Helix Stabilized by a Main Chain Hydrogen-Bond Surrogate
收藏NIAID Data Ecosystem2026-03-06 收录
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Herein we report the 1.15 Å X-ray crystal structure of a short α-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon−carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived α-helix truly resembles the structure of canonical α-helices and provides unequivocal support for our helix nucleation strategy.
创建时间：
2016-06-03
