A total of 58 genes were up-regulated (> 1.5 fold-change) while 117 genes were down-regulated Overall design: Microarray experiments were performed in duplicate as follows: MDA-MB-468 cells were trans
p53 gene is one of the most frequently altered gene in human cancers. It has 12 isoforms, out of which Δ40p53 is the only translational isoform of p53. p53 is already known to regulate a number of cel
This study is to find the cellular and molecular mechanisms by which a naturally-occurring ΔNp53 isoform causes accelerated aging in humans. The biological function of ΔNp53, which lacks only 40 N-ter
