Copper-Catalyzed Three-Component Alkene Carbofunctionalization: C–N, C–O, and C–C Bond Formation from a Single Reaction Platform
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A general system achieving three-component intermolecular carbofunctionalization of alkenes is presented, including carboetherification, carboesterification, carboarylation, and carboamination. The scope of the reaction is presented with respect to the carbon electrophile, the olefin, and the nucleophile. Furthermore, the synthesis of γ-lactams via a carboamination reaction is demonstrated in a telescoped three-step protocol.
创建时间：
2021-06-07
