Palladium-Catalyzed Intermolecular Trans-Selective Carbofunctionalization of Internal Alkynes to Highly Functionalized Alkenes
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https://figshare.com/articles/dataset/Palladium-Catalyzed_Intermolecular_Trans-Selective_Carbofunctionalization_of_Internal_Alkynes_to_Highly_Functionalized_Alkenes/12909719
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资源简介：
A palladium/DPEphos-catalyzed
intermolecular trans-selective carbofunctionalization
of internal alkynes has been established herein. This method proceeds
through a formal anti-carbopalladation, forming trans-alkenyl palladium species, which was trapped by aryl boronic acids
to provide all-carbon tetrasubstituted alkenes in 32–92% yields.
The trans-selective arylsilylation/remote C–H silylation and
hydroarylation/remote C–H borylation of internal alkynes were
also achieved using hexamethyldisilane and bis(pinacolato)diboron
as trapping reagents, respectively. The reaction features good regio-
and stereoselectivity and high functional group tolerance. A preliminary
mechanistic study and DFT calculations show that a cis to trans isomerization
of cis-alkenyl palladium species was involved in
this transformation.
创建时间：
2020-09-02
