Neurospora Intermedia as a Rare Cause of Invasive Fungal Infection in Humans. Neurospora intermedia

Neurospora intermedia, an edible filamentous fungus, is commonly used for production of fermented food. This study described four N. intermedia isolates recovered from three patients. Two isolates were recovered from endotracheal aspirate and from tissue biopsy of endobronchial mass 3 days later, respectively, of a patient with chemotherapy-refractory mediastinal germ cell tumor; both isolates are genetically related and belonged to mating type a. PacBio whole genome sequencing and assembly of the tissue isolate yielded 15 contigs with a genome size of approximately 41.7Mb. The other two isolates were recovered from endotracheal aspirates of two patients with probable invasive pulmonary aspergillosis, respectively, and both belonged to mating type A. The crude extracts of isolates from three patients cross-reacted with Aspergillus galactomannan antigen testing. All four isolates were susceptible to amphotericin B and voriconazole.