Proteomics characterization of Chromosomal Common Fragile Site (CFS) - associated proteins uncovers ATRX as a regulator of CFS stability

Chromosomal Common Fragile Sites (CFSs) are conserved regions of our genome prone to break in conditions of replication stress (RS. Here, we have performed Chromatin Immunoprecipitation (ChIP) with FACND2 antibodies coupled to Mass Spectrometry to isolate CFSs from HeLa cells and identify the proteins enriched at these loci.