Microarray analysis of embryonic E15 mouse gonads from control male, female and Amh; Inhbb dKO males

Fate determination and maintenance of fetal testes in most mammals occur cell autonomously as a result of the action of key transcription factors in Sertoli cell. In the mouse testis AMH and Activin B are required for the maintenance of Sertoli cell fate. In the absence of both AMH and Activin B initial testis differentiation (E12.5) occurs normally but, by embryonic day 15.5, Sertoli cells at the testis poles transdifferentiate into granulosa cells. We compared the transcriptional profile of control testis, control ovaries and dKO (Amh-/-; Inhbb-/-) testis at embryonic day 15.5