Overview of the phenotypes of CebpaS248A/S248A and CebpaKI/KI mice.

NIAID Data Ecosystem2026-03-07 收录

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https://figshare.com/articles/dataset/_Overview_of_the_phenotypes_of_Cebpa_S248A_S248A_and_Cebpa_KI_KI_mice_/297684 数据链接链接失效反馈

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资源简介：

Overview of the phenotypes of CebpaS248A/S248A and CebpaKI/KI mice.

创建时间：

2012-06-08

Single-cell RNA sequencing of myeloid cells, hematopoietic stem and progenitor cells, and mesenchymal stromal cells isolated from bone marrow of C57BL/6J WT and IL-1rn-KO mice. Single-cell RNA sequencing of myeloid cells, hematopoietic stem and progenitor cells, and mesenchymal stromal cells isolated from bone marrow of C57BL/6J WT and IL-1rn-KO mice

单细胞转录组学

血液疾病模型

Interleukin-1β (IL-1β) drives hematopoietic stem cell (HSC) differentiation into the myeloid lineage, and enhanced IL-1β signaling plays a key role in hematological malignancies. However, little is kn

NIAID Data Ecosystem50

ZRSR1 cooperates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells

剪接机制调控

血液疾病模型

Recurrent loss-of-function mutations of spliceosome gene, ZRSR2, occur in myelodysplastic syndromes (MDS). Mutation/loss of ZRSR2 in human myeloid cells primarily causes impaired splicing of the U12-

NIAID Data Ecosystem30

Single cell RNA seq of bone marrow cells from mouse MDS disease model and WT control

单细胞RNA测序

血液疾病模型

mDia1-miR146a double knockout (DKO) mice develop aging related MDS and eventually progress to AML at moribund stage. To investigate the rescue effect from IL6 deficiency, we created mDia1-miR146a-IL6

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A Dual Reporter Mouse Model of the Human β-Globin Locus: Applications and Limitations

珠蛋白基因调控

血液疾病模型

The human β-globin locus contains the β-like globin genes (i.e. fetal γ-globin and adult β-globin), which heterotetramerize with α-globin subunits to form fetal or adult hemoglobin. Thalassemia is one

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FUNCTIONAL_ANALYSIS_OF_SF3B1_K700E_AND_SRSF2_P95H_MUTATIONS. FUNCTIONAL_ANALYSIS_OF_SF3B1_K700E_AND_SRSF2_P95H_MUTATIONS

剪接因子突变功能分析

血液疾病模型

The aim is that of investigating the consequences of SF3B1 K700E mutation in haematopoiesis by modeling it in the mouse animal model system. Because this mutation is thought to be gain-of-function and

NIAID Data Ecosystem30

Overview of the phenotypes of <i>Cebpa</i><sup>S248A/S248A</sup> and <i>Cebpa</i><sup>KI/KI</sup> mice.

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