Integrative proteo-transcriptomic characterization of advanced fibrosis in chronic liver disease across etiologies

Olink Data of 40 Healthy Individuals and 144 Patients with Chronic Liver Disease, including Chroniv Viral Hepatitis, Alcohol-related Liver disease, and Metabolic Dysfunction-associated Steatotic Liver Disease.

Inclusion and exclusion criteria:
The study included adults aged 18-80 years who can provide informed consent and have a confirmed diagnosis of chronic liver disease through clinical evaluation, imaging, and histopathological findings. General exclusion criteria encompassed the presence of acute liver disease and other chronic liver diseases, such as Budd-Chiari syndrome, Wilson’s disease, autoimmune hepatitis, and drug-induced liver disease. Additional exclusion criteria include concurrent severe systemic illnesses, such as advanced cardiovascular disease, sepsis, or any malignancy other than HCC. Participants who were pregnant or lactating and had a history of organ transplantation were also excluded. For patients with MASLD and ARLD, diagnosis-specific inclusion and exclusion criteria are determined following guidelines outlined by Rinella et. al., 2023 2. For those with CVH, inclusion criteria involve a diagnosis of chronic viral hepatitis confirmed by serological tests. Patients diagnosed with hepatocellular carcinoma (HCC) met the general background etiology criteria of MASLD, ARLD, or CVH and had histologically or radiologically confirmed HCC.