Microglia are brain-resident, myeloid cells that play important roles in health and brain pathologies. While data on chromatin accessibility in activated murine microglia are available, there is no su

NIAID Data Ecosystem30

Unexpected role of interferon-g in regulating neuronal connectivity and social behavior

神经免疫调控

社会行为分子机制

We identified an enrichment in IFN-gamma dependent genes in the prefrontal cortex of group housed mice compared to single housed mice. Mice were house either grouped or single for 6 days. Mice were eu

NIAID Data Ecosystem10

List of upregulated genes.

神经免疫调控

单细胞转录组学

Microglia, the resident immune cells of the brain, are crucial in the development of the nervous system. Recent evidence demonstrates that microglia modulate adult hippocampal neurogenesis by inhibiti

NIAID Data Ecosystem50

Microglia P2Y6 receptor signaling regulates a broad range of innate immune responses after TLR engagement

神经免疫调控

小胶质细胞信号通路

We analyzed the transcriptomes of adult primary rhesus macaque microglia that were exposed to 10 µg/mL uLPS, in the absence or presence of 5 µM P2RY6 antagonist MRS2578 Primary microglia cultured in m

NIAID Data Ecosystem20

Effect of small molecules on activated astrocytes and microglia cells

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