The known targets of the NEDD4 family, the signaling pathways affected, and their expression levels in human cancers.

In the “Signaling pathways affected” and “Expression in cancer” columns, ↓ indicates inhibition and downregulation, respectively, while ↑ indicates activation and upregulation. Patched (PTC), epithelial sodium channel (ENaC), cyclic nucleotide ras GEF (CNrasGEF), androgen receptor (AR), B-cell CLL/lymphoma 10 (Bcl10), potassium voltage-gated channel, shaker-related subfamily, member 3 (Kv1.3), sodium/glucose cotransporter 1 (SGLT1), sodium channel, voltage-gated, type V (NaV1.5), amyloid beta A4 precursor protein-binding family B member 1 (Fe65), dopamine transporter (DAT), inhibitor of growth 2 (ING2).