Acyl-enzyme complex of ampicillin bound to deacylation mutant KPC-2 (E166Q)
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Acyl-enzyme complex of ampicillin bound to deacylation mutant KPC-2 (E166Q) Descriptor: (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... Authors: Tooke, C.L, Hinchliffe, P, Spencer, J. Deposit date: 2022-07-29 Release date: 2023-03-08 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase. J.Am.Chem.Soc., 145, 2023
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2022-07-29
