Metadata record for the manuscript: FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity

<b>Summary</b><br> This metadata record provides details of the data supporting the claims of the related manuscript: “FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity”.The related study aimed to determine the effect of Focal Adhesion Kinase (FAK) inhibition on breast Cancer Stem-like Cells (CSC) activity alone and in combination with adjuvant therapies.Type of data: flow: clinical data, mammosphere counts, tumour growth data and clinicopathological data.Subject of data: Homo sapiens, NOD scid gamma (NSG) mice, breast cancer cell lines.Sample size: 244 patients were included for IDC cohort. 26 Invasive Ductal Carcinoma samples were collected by the MCRC biobank on lesions with a pre-op size of &gt;1.5cm.Population characteristics: IDC cohort 1 recurrence: 2 non recurrence across molecular phenotypes.Recruitment: Human samples were recruited and consented by MCRC biobank (research ethics code 05/Q1403/159).Retrospective patient cohort work was approved by Health Research Authority for this work under project code REC14/SW/1170.<br><b>Data access</b><br> The following data are openly available as part of this figshare data record:- Mammosphere counts and tumour growth plots in the Prism file ‘<b>NPJ_data.pzfx</b>’;- Aldeluor FACS plots in the files ‘<b>SiRNA_ALDH.wsp</b>’ and ‘<b>RC37_ALDH.wsp</b>’;- Invasive ductal carcinoma cohort data in the SPSS file ‘<b>IDC_IHC.sav</b>’.For tissue staining for tFAK, ITGa6, Ki67 and ALDH, the associated files are available upon reasonable request from the corresponding author.<br><b>Corresponding author(s) for this study</b>N Bundred. Breast Biology Group, Manchester Breast Centre, Oglesby Cancer Research Building, University of Manchester, 555 Wilmslow Road, M20 4GJ. [e-mail] Farnie. Cancer Stem Cell Research, Oglesby Cancer Research Building, University of Manchester, M20 4GJ. [e-mail]<br> <b>Study approval </b> All procedures were performed in accordance with the Animals Scientific Procedures Act 1986 and approved by the UK home office. Project License 40/3645.Invasive Ductal Carcinoma Cohort: ethics code REC14/SW/1170; Isolation of epithelial cells from human tumour samples: ethics code: 05/Q1403/159.