DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.
收藏PubMed Central1991-11-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC52799/
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资源简介：
In the yeast Saccharomyces cerevisiae, as in other eukaryotes, some regions of the genome have a much higher rate of meiotic recombination than others. We show below that the binding of the RAP1 protein to a site upstream of the HIS4 gene is necessary for a high rate of meiotic (but not mitotic) recombination at this locus. A mutation in the RAP1 binding site at HIS4 results in a decrease in recombination; overproduction of RAP1 causes an increase in recombination at HIS4 above wild-type levels. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1991-11-01
