Alanine ameliorates AKI-to-CKD transition via restoring metabolism reprogramming through inducing DBP-MCT2 signaling

Accumulating evidence indicate that metabolic disturbances contribute to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD), but the molecular mechanisms and therapeutic strategies remain poorly understood. In this study, we quantified the levels of 20 kinds of L-amino acids in the serum of patients and mice with renal ischemia-reperfusion injury (IRI).