Sequence variation in vaccine and challenge virus epitopes.

Sequence variations in known dominant NP T cell epitopes and M2e among influenza A viruses relevant to this study. Amino acids encoded by the challenge virus which differ from the A/PR/8/34 sequence are underlined. Amino acids encoded by the challenge virus which differ from the A/AA/6/60 sequence are bolded.*A/Ann Arbor/6/60 (A/AA/6/60) is the backbone virus of the ca viruses used in this study.