Human cytomegalovirus (HCMV) co-infection is highly prevalent within HIV-1 cohorts and is an important cofactor in driving ongoing immune activation, even during effective antiretroviral treatment. HC
T-bet and Eomes are transcription factors that are known to be important in maturation and function of murine natural killer (NK) cells. Reduced T-BET and EOMES expression results in dysfunctional NK
NK-specific grp94 deficiency decreased mature NK cells in mice, and these grp94-deficient NK cells exhibited undermined activation, cytotoxicity, and IFN-gamma production upon stimulation and weakened
