Mortality rate ratio (MRR) of HIV-infected individuals initiating HAART after 1 January 1998 with a VL 500copies/ml) comparing time on statin with time not on statin.

Abbreviations: MRM: Mortality Rate Ratio; 95% CI: 95% Confidence Interval; PYR: Person years of follow-up; MSM: men who have sex with men; HAART: Highly Active Antiretroviral Therapy.*Adjustment 1: Adjusted for age (treated as time-updated variables split at 30, 40, 50, 60,70), gender, race, HIV transmission group, CD4 cell count at HAART initiation (200 cells/µl), HIV VL at HAART initiation (log10 VL), total cholesterol (8, missing values), year of HAART initiation ( = 2004), ART prior to HAART, AIDS defining illness prior to HAART initiation, Viral hepatitis C co-infection.*Adjustment 2: Adjusted for variables as in model 1 + comorbidity and the clinically important interaction between comorbidity and statin use/non-use, The MRRs are therefore presented both before and after development of a comorbid condition. Comorbidity is defined as the first of the following comorbid conditions: coronary artery disease, cerebrovascular disease, peripheral artery disease, chronic kidney disease and a redeemed prescription of an antidiabetic drug and introduced as a time-updated variable.