Electrophysiology-Compatible Wearable Transcranial Focused Ultrasound Neuromodulation Array Probes (Ultrasound Characterizations: Computer Simulations)

We designed and simulated a novel 64-element random array ultrasound transducer which is electrophysiology-compatible and is wearable. The project promises to develop a wearable ultrasound neuromodulation transducer array system, integrated with electrophysiological recordings in awake behaving animals, thus significantly advancing our ability to interrogate neural circuits in various behaving animal models with a high spatiotemporal resolution and has tremendous potential for translation to clinical utility. This dataset includes 5 .mat files with formatted transcranial focused ultrasound simulation pressure magnitude data (variable: us_mag). Each file name is marked with the transcranial brain targets, e.g., S1HL, insula, thalamus, that are responsible for pain signal processing. Other two .mat files have the formatted ultrasound pressure field when the ultrasound targets at a sham location or when the transducer is working in the coherent mode, i.e., all elements transmitting ultrasound simultaneously. When the tFUS targeted at S1HL, insula, thalamus and sham locations, the H276 was steering its focus by certain distances. These distances were listed in our preprinted work shown below. The spatial step sizes of the 3D matrix (us_mag) are included in each of these files (variable: delta_x, delta_y, delta_z). The simulations were implemented in Sim4Life V7.0 in the presence of a mouse skull model (CT image based). This work was supported in part by NIH EB029354, NS124564, and NS131069. More information can be found in the corresponding manuscript: