Multi-omics analysis reveals the molecular mechanisms of gut microbiota in Parkinson's disease (PRJCA043238)

PD is the second most common neurodegenerative disorder, marked by motor and GI symptoms. Gut microbiota dysbiosis is closely involved in PD pathogenesis. Our study shows that PD patient-derived microbiota induces PD-like symptoms in the GF mice. By leveraging a multi-omics approach including midbrain snRNA-seq, fecal metagenomics, and serum metabolomics, it suggests that gut microbiota dysbiosis may drive the metabolic alterations that compromise BBB integrity, ultimately promoting dopaminergic neurodegeneration. Notably, microbiota-derived bile acid DCA emerges as a critical contributor to disease progression.