CHANGES IN HEMOSTASIS PARAMETERS DURING PREGNANCY COMPLICATED BY VARICOSE VEINS AND A DIFFERENTIAL APPROACH TO THEIR CORRECTION

The physiological state of pregnancy naturally induces a profound hypercoagulable shift designed to minimize bleeding during parturition. However, when this natural adaptation is compounded by the presence of varicose veins of the lower extremities, the risk of developing life-threatening venous thromboembolism increases exponentially. This research investigates the specific alterations in hemostatic and rheological blood parameters among pregnant women suffering from varicose disease and evaluates the clinical efficacy of a differential, severity-based approach to pharmacological and mechanical correction. Through a comprehensive prospective clinical study involving serological analyses across different trimesters, researchers meticulously monitored markers such as fibrinogen, D-dimer, activated partial thromboplastin time, and soluble fibrin monomer complexes. The integrated literature review synthesizes current global perspectives on Virchow’s triad within the context of obstetric pathology, highlighting the detrimental synergy between venous stasis, endothelial dysfunction, and gestation-induced hypercoagulability. Empirical findings demonstrate that pregnant women with unmanaged varicose veins experience severe, pathological spikes in procoagulant markers during the third trimester, far exceeding normal physiological ranges. Conversely, the implementation of a targeted differential approach utilizing graduated compression therapy, phlebotonics, and low molecular weight heparins specifically tailored to the clinical and laboratory severity of the condition significantly stabilized the hemostatic profile. The discussion emphasizes the critical necessity of transitioning from a uniform prophylactic strategy to an individualized therapeutic paradigm. Ultimately, routine advanced hemostasis monitoring combined with differential correction is strongly advocated to mitigate thrombotic risks, thereby safeguarding both maternal and fetal well-being throughout the gestational period.