Transcriptome data of bone marrow hematopoietic stem cells (HSCs) with premature aging

Recent advances have taken advantage of various animal models in HSC aging research, including certain gene mutations, chemicals, and ionizing radiation (IR). To identify the underlying mechanisms and phenotype switching in HSC aging, we employed IR-induced premature HSC aging model and performed RNA-seq of HSCs from the bone marrow (BM) of mice at three months post IR and their age-matched control mice (Ctrl). We then performed gene expression profiling analysis using data obtained from RNA-seq of BM HSCs (Lineage-Sca-1+c-Kit+CD150+Flt3-CD48-) of control or IR mice.