Dynamics of synthetic yeast chromosome evolution shaped by hierarchical chromatin structures. Dynamics of synthetic yeast chromosome evolution shaped by hierarchical chromatin structures

To investigate the mechanisms underlying the rearrangement patterns,we compared the rearrangement map with local chromatin structures and the three-dimensional genome architecture via assay for transposase-accessible chromatin using sequencing (ATAC-seq) and genome-wide chromosome conformation capture (Hi-C), respectively Overall design: ATAC-seq and Hi-C of synthetic strain yZSJ025