Epigenome-Wide Association Study in multiple system atrophy (MSA)

Genome-wide methylation profiling of DNA extracted from the prefrontal cortex of post-mortem MSA patients (n=41) or normal, healthy controls (CTRLs; n=37). The Illumina Infinium MethylationEPIC BeadChip was used, investigating app. 850,000 CpG sites throughout the genome Bisulphite (BS) or oxidative bisulphite (oxBS) converted DNA from 78 samples (41 MSA, 37 CTRL) were hybridized to the Illumina Infinium MethylationEPIC BeadChip.