ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost

NIAID Data Ecosystem2026-03-12 收录

抗肿瘤药物递送

血脑屏障通透性

数据链接：

https://data.mendeley.com/datasets/vkxm4zp7s3 数据链接链接失效反馈

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资源简介：

Raw data / figures for manuscript

创建时间：

2020-12-17

可视化活细胞多功能药物递送体系的肿瘤靶向深处渗透及肿瘤滞留数据集

抗肿瘤药物递送

活体成像药代动力学

共65例文件，共130 MB，通过构建肿瘤模型动物，尾静脉注射活细胞多功能药物递送体系，利用小动物活体成像仪器观察肿瘤部位的药物荧光蓄积以及肿瘤部位荧光代谢等情况；处死老鼠，收集心、肝、脾、肺、肾、肿瘤等主要脏器，通过活体影像跟踪肿瘤内药物在各脏器的荧光分布情况；收集肿瘤样品，一部分研磨，利用流式细胞仪分析肿瘤组织中药物荧光分布；另一部分，液氮速冻后，冷冻切片，利用共聚焦显微镜分析肿瘤组织中药物荧

国家人口健康科学数据中心30

DataSheet_1_3,5,3′-Triiodothyronine–Loaded Liposomes Inhibit Hepatocarcinogenesis Via Inflammation-Associated Macrophages.docx

抗肿瘤药物递送

微环境调控

BackgroundHepatocellular carcinoma (HCC) is inflammation-related cancer. Persistent inflammatory injury of the liver is an important factor mediating the occurrence and development of liver cancer. He

NIAID Data Ecosystem30

Supplementary Material for: Differential Blood–Brain Barrier Permeability Driven by Asymmetric Hypoperfusion in a Vascular Dementia Model

血管性痴呆

血脑屏障通透性

Background: Blood-brain barrier (BBB) dysfunction has been associated with vascular dementia (VaD). However, the underlying mechanisms causing BBB dysfunction remain unclear, especially regarding cere

NIAID Data Ecosystem10

NGR-peptide−drug conjugates with dual targeting properties

抗肿瘤药物递送

抗肿瘤活性

Peptides containing the asparagine-glycine-arginine (NGR) motif are recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature. Spontaneous

NIAID Data Ecosystem30

Additional file 2: of Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

血脑屏障通透性

基因本体功能

Table S2. Gene ontology analysis. Gene ontology analysis was performed using the DAVID bioinformatics tools. The enriched functional annotation clusters are listed along with p values for LPS vs Sham

NIAID Data Ecosystem20

ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost

资源简介：

相关数据集