Supplementary results.

Fig A. Funnel plots for the effect of never smoking status on risk of self-reported fatigue for each single-nucleotide polymorphism (SNP), the resulting Mendelian randomization (MR) estimate is plotted against the inverse of the standard error of the MR estimate. Symmetry noted in this plot provides evidence against the presence of directional horizontal pleiotropy. The inverse-variance weighted and MR Egger causal estimates are represented by a red and blue line respectively. Fig B. Funnel plots for the effect of current smoking status on risk of self-reported fatigue for each single-nucleotide polymorphism (SNP), the resulting Mendelian randomization (MR) estimate is plotted against the inverse of the standard error of the MR estimate. Symmetry noted in this plot provides evidence against the presence of directional horizontal pleiotropy. The inverse-variance weighted and MR Egger causal estimates are represented by a red and blue line respectively. Fig C. Funnel plots for the effect of alcohol intake frequency on risk of self-reported fatigue for each single-nucleotide polymorphism (SNP), the resulting Mendelian randomization (MR) estimate is plotted against the inverse of the standard error of the MR estimate. Symmetry noted in this plot provides evidence against the presence of directional horizontal pleiotropy. The inverse-variance weighted and MR Egger causal estimates are represented by a red and blue line respectively.
(ZIP)