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Dataset for "Modelling intramuscular drug fate in vitro with tissue-relevant biomimetic hydrogels"

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doi.org2025-03-24 收录
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https://doi.org/10.15125/BATH-01146
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The data covers the two areas addressed in the manuscript text: 1. Rheology of hydrogels formed from bovine type-1 collagen (Col1) with/without hyaluronic acid (HA) supplementation. This data addressed a) what were the viscoelastic properties of Col1 hydrogels and b) whether HA supplementation affected these properties in any way. 2. 96-well plate fluorescence data describing the cumulative release of GFP from the hydrogel environments into the acceptor phase. Analysis of samples taken at defined time points from the SIMI created 24-hr pharmacokinetic profiles, to visualise cumulative release over the experimental time period.

本数据集涵盖了文稿文本中探讨的两个领域: 1. 针对从牛型-1胶原蛋白(Col1)与/或透明质酸(HA)补充剂形成的凝胶的流变学特性进行研究。数据集探讨了以下问题:a) Col1凝胶的粘弹性特性如何;b) HA补充剂是否以任何方式影响了这些特性。 2. 96孔板荧光数据描述了从水凝胶环境中到受体相的GFP累积释放。通过分析从SIMI中在规定时间点采集的样本,创建了24小时的药代动力学轮廓,以可视化实验时间周期内的累积释放情况。
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