Reactome pathway and GO term enrichment analysis results.

Sheets 1–4: Enriched Reactome pathways. Lists of mouse gene names of significantly differentially expressed genes (S2 Table) were used for Reactome pathway enrichment [11], in which they were converted to their human orthologues and analysed to determine which pathways are significantly over-represented. Input gene lists are indicated in the sheet name, for example ‘Reactome_TS_up’ shows the Reactome enrichment results generated using the ‘TS_up’ list from S2 Table as input. Sheets 5–8: Enriched GO terms. The same differentially expressed mouse gene lists were used for GO term enrichment analysis by PANTHER [114], against a background list of all the genes which passed the threshold for inclusion in that expression analysis. Column labels are as described in both Reactome and PANTHER user guides. All results with significant p values (≤ 0.05) are shown. (XLSX)