Fig.S6. MERS-CoV Virus-Human Protein Interaction Network.

Virus-human protein protein interaction map depicting high-confidence interactions (MiST >= 0.7 & Saint BFDR <= 0.05 & Average Spectral Counts >= 2) for MERS-CoV as derived from affinity purification-mass spectrometry (AP-MS). Viral bait proteins are depicted with yellow diamonds and human proteins with dark grey circles. Human-human interactions are depicted in thin, dark grey lines. Proteins within the same protein complexes or biological process are indicated with light yellow or light blue highlighting, respectively, and annotated accordingly. Human-human physical interactions, protein complex definitions, and biological process groupings are derived from CORUM (39), Gene Ontology (biological process), and manually curated from literature sources. Thin dashed grey lines are used to indicate the placement of node labels when adjacent node labels would have otherwise been obscured.