The serum mRNA profile during disease progression in dengue virus infection

Dengue virus infection can be classified into 3 different groups based on disease severity (Plan A, Plan B and Plan C). As the disease progresses to a severe infection, there will be change in the profile of the secretory mRNAs in the patient’s serum. This change may be a basis of disease progression, as these mRNAs may absorb by new cells and further aid or supress virus infection. Hence, in this study we wanted to examine the secretory mRNAs in human patient serum samples at different stages (Plan A, Plan B and Plan C) of dengue infection as compared to healthy control. This may help us in identifying the secretory mRNAs that are differentially regulated in dengue infection and how they help in progression to severe dengue.