Xestospongia muta derived marine actinomycetes. actinomycetes

NIAID Data Ecosystem2026-03-13 收录

海洋微生物药物发现

抗结核药物

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA820852 数据链接链接失效反馈

官方服务：

资源简介：

Strains of various actinomycetes genera were isolated from a Caribbean giant barrel sponge (X.muta) and investigated for the production of compounds that inhibit Mycobacterium

创建时间：

2022-03-28

Complete analysis of data from screening for antitubercular activity and physico chemical properties of the hit compounds.

抗结核药物

化合物活性分析

Rifampicin and Isoniazid were taken as controls. MIC values for controls against M. smegmatis are Rif-2.43±0.02μM and Inh-11.03±0.05 μM and H37Rv are Rif-0.08±0.01μM and Inh-0.22±0.3 μM.

NIAID Data Ecosystem60

Chemical structure, in vitro antimycobacterial activity against M. tuberculosis H37Rv , activity against M. tuberculosis H37Rv in the LORA, and cytotoxicity in Vero cells and HepG2 cells of compounds 5–25 .

抗结核药物

细胞毒性评估

aantimycobacterial activity against M. tuberculosis H37Rv. bantimycobacterial activity against M. tuberculosis H37Rv in the LORA. ccytotoxicity in Vero cells. dcytotoxicity in HepG2 cells.

NIAID Data Ecosystem30

Minimal inhibitory concentrations (MIC) of the ethyl acetate extract of Trixis angustifolia DC. (TxAcE) and trixanolides (1a and 1a’) against Mycobacterium tuberculosis H37Rv and nontuberculous mycobacteria.

抗结核药物

天然产物抗菌活性

NIAID Data Ecosystem20

EthR ligand complex

蛋白质-配体复合物结构

抗结核药物

EthR ligand complex Descriptor: 2-[2-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2,3-triazol-1-yl]ethyl]-6-methyl-1~{H}-pyrimidin-4-one, HTH-type transcriptional regulator EthR Authors: Pohl, E, Tatum, N.

Protein Data Bank Japan2024-01-24 更新30

Data_Sheet_3_Screening of Compounds for Anti-tuberculosis Activity, and in vitro and in vivo Evaluation of Potential Candidates.xls

抗结核药物

抗结核候选药物评价

Tuberculosis (TB) is a debilitating infectious disease responsible for more than one million deaths per year. The emergence of drug-resistant TB poses an urgent need for the development of new anti-TB

NIAID Data Ecosystem30

Xestospongia muta derived marine actinomycetes. actinomycetes

资源简介：

相关数据集